Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ MPNST Inhibitor, Cpd21
A cell-permeable. Reversible, selective inhibitor of the growth of malignant peripheral nerve sheath tumors (EC50 = 439 nM, 754 nM, and 1.0 μM in S462, SNF96.2, and sMPNST cells).
MilliporeSigma™ Calbiochem™ NOX Inhibitor VIII, VAS3947
VAS3947, NOXi.
MilliporeSigma™ Calbiochem™ Caspase-1/4 Inhibitor, VX-765
A cell-permeable prodrug that upon conversion to its active form inhibits caspase-1 and 4 activity (Ki = 800 pM and 600 pM, respectively).
MilliporeSigma™ Calbiochem™ Adenosine A3 Receptor Agonist, 2-Cl-IB-MECA
A highly selective agonist of adenosine A3 receptor (Ki = 330 pM).
MilliporeSigma™ Calbiochem™ IRAP Inhibitor, HFI-419
A substrate competitive inhibitor of insulin-regulated aminopeptidase (IRAP) activity (Ki = 0.48 μM against 25 μM Leu-AMC).
MilliporeSigma™ Calbiochem™ Mcl-1 Inhibitor II
A cell-permeable hydroxynaphthalenylthioacetate that targets Mcl-1 BH3-binding groove and selectively competes against 8nM FITC-AHA-BIM142-161 for Mcl-1, but not Bcl-xL, binding (IC50 = 310nM vs >40μM; [Mcl-1] & [Bcl-x
MilliporeSigma™ Calbiochem™ InSolution™ Ginkgolic Acid (15:1)
A 25 mM (2 mg/231 μl) sterile-filtered solution of Ginkgolic Acid (15:1) in DMSO.
MilliporeSigma™ Calbiochem™ InSolution™ EZH2 Inhibitor, DZNep
A 25 mM (1 mg/98 μL) sterile-filtered solution of Histone Methyltransferase EZH2 Inhibitor, DZNep in H2O.
MilliporeSigma™ Calbiochem™ Prokineticin 2 Antagonist, PKRA7
A cell permeable, brain permeant antagonist of polypeptide chemokine prokineticin 2 receptor (IC50 = 5 nM and 8.2 nM for PKR1 and PKR2, respectively).
MilliporeSigma™ Calbiochem™ InSolution™ Glutaminase Inhibitor, Compound 968
A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10μM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cel
MilliporeSigma™ Calbiochem™ Hydroxychloroquine Sulfate
A cell-permeable compound that increases intralysosomal pH and impairs autophagic degradation process. Suppresses proliferation of human dermal fibroblasts (IC50 = 30 μM).
Novus Biologicals™ Celastrol, IL-17A (IL-17A Inhibitor)
Used in assays to inhibit IL-17A induction
MilliporeSigma™ Calbiochem™ Glucokinase Activator II
A cell-permeable compound that reduces glucokinase Km for glucose (EC50 = 120 nM & 350 nM, for human and rat enzyme). Enhances insulin secretion from INS-1 cells upon glucose exposure.
MilliporeSigma™ Calbiochem™ BMI-1 Expression Inhibitor, PTC-209
A cell-permeable compound that downregulates cellular BMI-1 levels by inhibiting BMI-1 transcription.
MilliporeSigma™ Calbiochem™ MICAL-2 Inhibitor II, CCG-203971
A cell-permeable, restricted form of CCG-1423 with enhanced potency (IC50 = 4.2 μM vs 16.6 μM for PC-3 cell migration), but reduced off-target toxicity.